RRP8 Antibody - N-terminal region : HRP (ARP68567_P050-HRP)
Product Specifications
Gene Aliases
NML, KIAA0409
Gene ID
23378
Swiss Prot
O43159
Accession Number
NP_056139
Host
Rabbit
Reactivity
Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8
Target
RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Partner Proteins
RNF2; SIRT7; SIRT1; SUV39H1; USP39
Clonality
Polyclonal
Conjugation
HRP: Horseradish Peroxidase
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 80%; Dog: 85%; Guinea Pig: 91%; Horse: 85%; Human: 100%; Rabbit: 100%; Rat: 93%; Yeast: 90%
Format
Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
50kDa
Shipping Conditions
Wet Ice
Product Datasheet
Anti-RRP8 (ARP68567_P050-HRP) antibody
Protein Length
456
NCBI Gene Symbol
RRP8
NCBI GB Accession Number
RRP8
Host or Source
Rabbit
Protein Name
Ribosomal RNA-processing protein 8
Nucleotide Accession Number
NM_015324
Peptide Sequence
GPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLD
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