THOC7 Antibody - C-terminal region : Biotin (ARP67324_P050-Biotin)

THOC7 is required for efficient export of polyadenylated RNA. It acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

THOC2; RPA3; RPA2; RPA1; CKAP4; UBC; ZC3H15; TRMT112; PPIP5K2; THOC1; UBE3C; USP13; ZPR1; THOC5; VIM; S100A13; WDR36; ZCRB1; THOC3; ZNF606; THOC6; ALYREF; DDX39B; NIF3L1; CHD3; MED8; GOT2; MED18; MED22

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.