MYSM1 Antibody - C-terminal region : Biotin (ARP67188_P050-Biotin)
Selected Variant
ARP67188_P050-Biotin
Size: 100 µL
Product Specifications
Gene Aliases
2ADUB, BMFS4, 2A-DUB
Gene ID
114803
Swiss Prot
Q5VVJ2
Accession Number
NP_001078956
Host
Rabbit
Reactivity
Human, Dog, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human MYSM1
Target
MYSM1 is a metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. It preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. MYSM1 acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR) -induced gene activation.
Partner Proteins
UBC; DICER1; SUMO2; TUBB1; WDR77; STK38; PRMT5; KAT2B; HIST2H2AC; RBM10; KIF11; HSPA1A; HNRNPH1; EEF1A1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Dog: 86%; Human: 100%; Rabbit: 77%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
91kDa
Shipping Conditions
Wet Ice
Protein Length
828
NCBI Gene Symbol
MYSM1
NCBI GB Accession Number
MYSM1
Host or Source
Rabbit
Protein Name
Histone H2A deubiquitinase MYSM1
Nucleotide Accession Number
NM_001085487
Peptide Sequence
CLQKLLECMRKTLSKVTNCFMAEEFLTEIENLFLSNYKSNQENGVTEENC
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