SPG21 Antibody - C-terminal region : Biotin (ARP65713_P050-Biotin)

Product Specifications

Gene Name

Spastic paraplegia 21 (autosomal recessive, Mast syndrome)

Gene Aliases

MAST, ACP33, GL010, ABHD21, BM-019

Gene ID

51324

Swiss Prot

Q9NZD8

Accession Number

NP_057714

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPG21

Target

The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.

Partner Proteins

INCA1; SPRED2; DTX3L; CMTM5; TRIM9; DTX2; REEP6; FAM114A1; ATPAF2; EFHC2; CCDC33; CCDC102B; TRIM54; AGTRAP; CTPS2; S100B; PRPS1; KRT15; CRYAA; TRIM23; CUTC; ARL6IP1; IKZF3; MID2; RABAC1; TFG; TRAF2; TRAF1; TCF12; TCF4; UBC; GSK3A; DHX40; YLPM1; HMGCS1; AK

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

SPG21 is supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 79%; Rat: 86%; Sheep: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.