MOB1A Antibody - middle region: Biotin (ARP65687_P050-Biotin)
Product Specifications
Gene Aliases
MOB1, MATS1, Mob4B, C2orf6, MOBK1B, MOBKL1B
Gene ID
55233
Swiss Prot
Q9H8S9
Accession Number
NP_060691
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human MOB1A
Target
MOB1A is an activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MOB1A stimulates the kinase activity of STK38 and STK38L. MOB1A acts cooperatively with STK3/MST2 to activate STK38.
Partner Proteins
FAM9B; CMTM3; SEPT3; FAM118A; KANK2; TDO2; UBC; HECW2; ANKRD52; AMOT; ANKRD44; DOCK7; LRCH3; RASSF5; DOCK8; MOB2; SAV1; LRCH2; DOCK6; THOC2; PPP6R3; CRLF3; IPO11; LATS2; ANKRD28; LRCH1; STK38L; PPP6R1; RASSF2; PPP6R2; LATS1; YWHAH; STK4; STK3; PTPN14; PPP
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
MOB1A is strongly supported by BioGPS gene expression data to be expressed in Jurkat
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
25kDa
Shipping Conditions
Wet Ice
Protein Length
216
NCBI Gene Symbol
MOB1A
Protein Name
MOB kinase activator 1A
Nucleotide Accession Number
NM_018221
Curated Selection
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