KRT6A Antibody - middle region : Biotin (ARP64419_P050-Biotin)

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

TRIM54; KRT40; TFIP11; HGS; KRT38; SGTA; KRT31; KRT15; KRT13; KIFC3; GOLGA2; TRIM23; LGR4; EED; KDM1A; PAN2; Iqcb1; Nphp4; Cep290; Nphp1; Invs; UBC; ITGA4; ALB; UBASH3B; SHC1; GRB2; EPS15; CRK; AP2M1; CBL; CUL1; COPS5; CUL2; CUL5; CCDC85B; TCHP; CCDC53; K

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.