TNFRSF1B Antibody - N-terminal region : Biotin (ARP63782_P050-Biotin)

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

LTA; TNF; ADAM17; CSNK1A1; ZNF420; UBQLN1; TRAF1; PKN1; CD14; RIPK1; TRADD; TRAF2; TNFRSF1A; CHUK; TRAF6; TRAF3; ASB3; UBC; HIVEP3; TRAIP; TDP2; CAV1; STAT1; BMX; FANCD2; KRT18; SMURF2; TRIM37; TNFRSF1B

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.