TFRC Antibody - N-terminal region : HRP (ARP63718_P050-HRP)

TFRC is a cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

HUWE1; UBC; SGTA; CAV1; TP53; RAB8A; RANBP9; LGR4; MDM2; RPA3; RPA2; RPA1; ASB4; RNF2; OPTN; ADRB2; CLN3; MARCH8; env; MARCH1; MYO1G; VCAM1; ITGA4; FN1; ATF2; B4GALT1; ESR1; ATP6V1B1; FBXO6; KCNA5; KCNA3; vpu; SH3BP4; PARK2; LAPTM4B; LAPTM4A; HGS; SUMO2

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.