PDE6B Antibody - C-terminal region : FITC (ARP63580_P050-FITC)
Selected Variant
ARP63580_P050-FITC
Size: 100 µL
Product Specifications
Gene Name
Phosphodiesterase 6B, cGMP-specific, rod, beta
Gene Aliases
Rd1, PDEB, RP40, CSNB3, CSNBAD2, GMP-PDEbeta
Gene ID
5158
Swiss Prot
E7ETT3
Accession Number
NP_001138764
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Target
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Partner Proteins
PPP1CC
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 86%; Dog: 86%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 79%; Rat: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
98kDa
Shipping Conditions
Wet Ice
Protein Length
854
NCBI Gene Symbol
PDE6B
NCBI GB Accession Number
PDE6B
Host or Source
Rabbit
Protein Name
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta Ensembl ENSP00000406334
Nucleotide Accession Number
NM_001145292
Peptide Sequence
RQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLS
Subunit
Beta
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