WASL Antibody - middle region : FITC (ARP63498_P050-FITC)

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.

RHOJ; ARPC3; RNF8; NCK2; WIPF1; SDCBP; PTK6; GRB2; IQGAP1; WWOX; SNX9; APBB1; PRPF40A; FNBP1L; FNBP1; TRIP10; PSTPIP1; ACTG1; SORBS3; ACTR2; ACTR3; LCK; CDC42; RPL7AP66; ZNF395; BAIAP2; ARPC1B; FCHSD2; IPO5; HP; HSP90AB1; HSP90AA1; SRC; WASF2; APP; WIPF2

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.