MCAM Antibody - middle region: FITC (ARP63483_P050-FITC)
Product Specifications
Gene Name
Melanoma cell adhesion molecule
Gene Aliases
CD146, MUC18, HEMCAM, METCAM, MelCAM
Gene ID
4162
Swiss Prot
P43121
Accession Number
NP_006491
Host
Rabbit
Reactivity
Human, Cow, Horse, Pig, Rabbit
Target
MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. MCAM could be an adhesion molecule active in neural crest cells during embryonic development. MCAM acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Partner Proteins
ADRB2; UBC; HSP90AA5P; HSPA1L; ATF7IP; PTK2B; FYN
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
There is BioGPS gene expression data showing that MCAM is expressed in 721_B, HepG2, Jurkat
Concentration
0.5 mg/mL
Homology
Cow: 86%; Horse: 86%; Human: 100%; Pig: 86%; Rabbit: 79%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
71kDa
Shipping Conditions
Wet Ice
Protein Length
646
NCBI Gene Symbol
MCAM
Protein Name
Cell surface glycoprotein MUC18
Nucleotide Accession Number
NM_006500
Curated Selection
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