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MCAM Antibody - C-terminal region : HRP (ARP63482_P050-HRP)

Selected Variant

ARP63482_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Melanoma cell adhesion molecule

Gene Aliases

CD146, MUC18, HEMCAM, METCAM, MelCAM

Gene ID

4162

Swiss Prot

P43121-2

Host

Rabbit

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human MCAM

Target

MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. MCAM could be an adhesion molecule active in neural crest cells during embryonic development. MCAM acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

Partner Proteins

ADRB2; UBC; HSP90AA5P; HSPA1L; ATF7IP; PTK2B; FYN

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that MCAM is expressed in HepG2

Concentration

0.5 mg/ml

Homology

Dog: 79%; Guinea Pig: 77%; Horse: 79%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 79%; Rat: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

57kDa

Shipping Conditions

Wet Ice

Protein Length

527

NCBI Gene Symbol

MCAM

NCBI GB Accession Number

MCAM

Host or Source

Rabbit

Protein Name

Cell surface glycoprotein MUC18

Peptide Sequence

STSTASPHTRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFL

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