ABI1 Antibody - N-terminal region : Biotin (ARP63431_P050-Biotin)

This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t (10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.

ABL1; UBC; PRPF40A; TCERG1; GAS7; APBB1; SRRM1; PRKAA1; PIK3R1; CDC123; CTTN; NCK2; NCK1; CBL; CACNA1A; RYK; EPS8L1; ENAH; MINK1; EVL; NIN; CYFIP2; HSPA8; WASF2; WASF1; PAK2; NCKAP1; ABI1; VASP; SOS2; EPS8; NCF1; SPTA1; SPTAN1; SOS1; NEB; EPS8L3; EPS8L2

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.