MME Antibody - C-terminal region : Biotin (ARP63365_P050-Biotin)

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts.

MME; NPPA; AGT; HDAC8; UBC; NDRG1; FAM83F; RGPD6; POTEI; TUBB8; UBAC2; KBTBD3; MTDH; ITFG3; ARMC10; FAHD1; CDK5RAP3; MRPL44; NUCKS1; MRPS25; LAMTOR1; DNAJB12; SDF4; METTL7A; NNT; CPSF6; PDIA5; RUVBL2; TM9SF1; MRVI1; CLEC4M; ZMPSTE24; RBM39; ATP5J2; SLC9A3

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.