PLAUR Antibody - N-terminal region : Biotin (ARP63076_P050-Biotin)

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

TEX101; PLAU; LYN; ELAVL1; VMA21; TXNDC17; SCAF4; SDHAF2; UBQLN2; WDHD1; SELENBP1; TBCA; PSAP; CTSA; OXCT1; NOTCH2; HDLBP; CTTN; LRP1B; SURF2; SRPX2; MMP12; IL6ST; FAP; KNG1; VTN; TYK2; PFN2; JAK1; HCK; FYN; ITGB1; EEF1A1; ITGAM; LRP1; IGF2R; ITGB2; PDGFR

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.