RPA2 Antibody - C-terminal region : Biotin (ARP62495_P050-Biotin)

RPA2 functions as component of the alternative replication protein A complex (aRPA) . aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. FUNCTION: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.

HUWE1; APITD1; STRA13; FBXO18; UBC; PPP1R10; PPP1CC; POLR2E; POLA1; EXOSC10; PRDX1; NUMA1; NTHL1; NPM1; NONO; NCL; NBN; HNRNPM; PPP1R12A; MYO1E; MYO1C; MYH11; MYH10; MYH9; MYO1F; MTHFD1; MSH3; MSH2; MYO1B; MRE11A; MPG; MOV10; MNAT1; RAB8A; MAP4; CAPRIN1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.