CTPS2 Antibody - N-terminal region : Biotin (ARP62443_P050-Biotin)

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

CTPS2; SPG21; RNF2; LRSAM1; EHD4; EHD1; PLIN3; MTMR2; WARS; PRKDC; NUCB1; METTL1; KTN1; HSF1; GTF2I; DHPS; RPL37A; RPL23A; FGFR1; CTBP2; UBC; SUMO2; OTUD5

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.