BAG4 Antibody - C-terminal region: Biotin (ARP61938_P050-Biotin)

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

EDC3; DCP1A; DNAJB12; DNAJC9; CD93; STUB1; DNAJB6; MLF2; DNAJC7; DNAJB1; HSPA8; HSPA2; HSPA1L; HSPA1B; DDX6; DCP1B; MCL1; CAND1; DCUN1D1; COPS5; CUL1; CUL2; CUL3; CUL4A; CUL5; NEDD8; ELAVL1; UBC; TNFRSF25; APOBEC1; TNFRSF1A; BCL2; HSPA1A; HSP90AA1; HSPA4

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.