EIF3A Antibody - C-terminal region : Biotin (ARP61702_P050-Biotin)

Product Specifications

Gene Name

Eukaryotic translation initiation factor 3, subunit A

Gene Aliases

EIF3, P167, p180, p185, TIF32, EIF3S10, eIF3-p170, eIF3-theta

Gene ID

8661

Swiss Prot

Q14152

Accession Number

NP_003741

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish

Target

EIF3A is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

Partner Proteins

UBC; REL; TFIP11; WWP2; SUMO2; STAU1; LGR4; WWOX; EED; SHFM1; RNF2; EIF3CL; YTHDF2; LARP1; NUDT21; EIF3C; DYNC1I2; RPS26; RPS25; RPS23; RPS20; RPS18; RPS12; RPS10; RPS9; RPS3A; RPS3; FBXO6; TARDBP; EIF3D; UBD; ICAM1; CD81; RIOK2; IGSF8; BBS4; BBS1; gag-po

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

There is BioGPS gene expression data showing that EIF3A is expressed in HeLa

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.