HARS Antibody - N-terminal region : Biotin (ARP61337_P050-Biotin)

Product Specifications

Gene Name

Histidyl-tRNA synthetase

Gene Aliases

HRS, HARS, CMT2W, USH3B

Gene ID

3035

Swiss Prot

P12081

Accession Number

NP_002100

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human HARS

Target

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.

Partner Proteins

UBC; AARSD1; ACBD3; ELAC2; XPO5; THG1L; NSUN2; RPUSD2; SNF8; IPO7; EFTUD2; TTC1; SHMT1; PFDN1; GTF2E1; FEN1; CALU; PI4KA; G6PD; EIF2D; ANXA5; UBD; SUMO1; TNIK; STAM; EIF3I; EEF1G; RPL5; EEF1B2; TARS

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

HARS is supported by BioGPS gene expression data to be expressed in HEK293T

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.