NS-398
NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
Product Specifications
CAS Number
123653-11-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/NS-398.html
Purity
99.71
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2CCCCC2)=O
Molecular Formula
C13H18N2O5S
Molecular Weight
314.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Futaki N, et al. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994 Jan;47 (1) :55-9.|[2]Futaki N, et al. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993 Jan;24 (1) :105-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Monoclonal Pancreatic Lipase Antibody (120) [DyLight 650]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP2-90231C 0.1 mL
Rabbit Monoclonal Pancreatic Lipase Antibody (120) [DyLight 650]
Sign In for Pricing
View Details 
M3007-20E-PE 200 µL
MET (HGF Receptor, HGFR, Hepatocyte Growth Factor Receptor, Scatter Factor Receptor, SF Receptor, HGF/SF Receptor, Tyrosine-Protein Kinase Met, Proto-Oncogene c-Met) (PE) discontinued
Sign In for Pricing
View Details MBS1463515-01 0.02 mg (E-Coli)
Recombinant Staphylococcus aureus UPF0374 protein MW1807 (MW1807)
Sign In for Pricing
View Details