KLC1 Antibody - C-terminal region : HRP (ARP61154_P050-HRP)

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.

CCDC114; KRT31; BNIP2; UBC; EZH2; TLE3; KIF5B; DIAPH1; COPB1; ARCN1; KLC4; KLC2; SMEK2; PTPN23; COPZ1; APP; RIC3; BSDC1; FAM63B; PRKAG3; LDLRAP1; RASSF8; YWHAE; SKP1; SNCA; KIF5A; MAPK6; YWHAB; LRSAM1; MAPK8IP3; PLEKHM2; CLSTN1; SPAG9; MAPK8IP2; MAPK8IP1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.