PPP1R12A Antibody - C-terminal region : Biotin (ARP61148_P050-Biotin)

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP) -bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase.

TP53; UBC; NUAK1; RPA3; RPA2; RPA1; TRIM47; AARSD1; PUS1; P3H1; RPRD1B; XPO5; OSGEP; NSUN2; NUSAP1; TTLL12; NUDT5; ARPC2; ACTR3; CUL1; TPP2; PFDN5; PFDN1; NRD1; PAN2; LATS1; gag; FMNL1; PAXIP1; IDH3G; CDV3; RHOA; LRRK2; ATXN10; SIAH2; FBXO25; ARRB2; ELAVL

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.