SORD Antibody - N-terminal region : Biotin (ARP61128_P050-Biotin)

Product Specifications

Gene Name

Sorbitol dehydrogenase

Gene Aliases

RDH, SDH, XDH, SORD1, SORDD, HEL-S-95n

Gene ID

6652

Swiss Prot

Q00796

Accession Number

NP_003095

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SORD

Target

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]) . The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD (+) cofactor.

Partner Proteins

SORD; SUMO2; UBC; C12orf10; BCCIP; NAGK; CHORDC1; ACOT7; DDX39A; GDA; THOP1; TCEA1; TALDO1; SMS; PLS3; PGD; NME1; LDHA; FDPS; RELA; C16orf13; FLAD1; PIEZO1; TPM1; RANGAP1; RAD23A; PFDN4; GCLM; ETFA; AKR1B1; NUDCD2; LOC440434; TIPRL; SHBG

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

SORD is strongly supported by BioGPS gene expression data to be expressed in HeLa

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 86%; Guinea Pig: 83%; Horse: 93%; Human: 100%; Mouse: 79%; Pig: 93%; Rabbit: 86%; Rat: 93%; Sheep: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.