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Casp3 Antibody - middle region: FITC (ARP60988_P050-FITC)

Product Specifications

Gene Name

Caspase 3, apoptosis-related cysteine peptidase

Gene Aliases

Ya, AC-, CC3, CPP, mld, AC-3, Casp, Lice, Yama, mldy, CPP32, SCA-1, CASP-3, CPP-32, Caspase-3, A830040C14Rik

Gene ID

12367

Swiss Prot

P70677

Accession Number

NP_033940

Host

Rabbit

Reactivity

Human, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of Mouse Casp3

Target

Casp3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond, cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain, cleaves and activates caspase-6, -7 and -9, triggers cell adhesion in sympathetic neurons through RET cleavage, cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.

Partner Proteins

Dffb; Gzmb; Arhgdia; Sptan1; Rock1; Ctnnb1; Bid; Dffa; FEM1B; Psme3; Ubc; Slc1a2; Ywhae; Birc3

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/mL

Homology

Cow: 100%; Dog: 93%; Goat: 93%; Guinea Pig: 85%; Horse: 92%; Human: 86%; Pig: 93%; Rat: 92%; Sheep: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

31kDa

Shipping Conditions

Wet Ice

Protein Length

277

NCBI Gene Symbol

CASP3

Protein Name

Caspase-3

Nucleotide Accession Number

NM_009810

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