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PANK2 Antibody - middle region : FITC (ARP60834_P050-FITC)

Selected Variant

ARP60834_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Pantothenate kinase 3

Gene Aliases

HSS, HARP, PKAN, NBIA1, C20orf48

Gene ID

80025

Swiss Prot

Q9BZ23-4

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of HUMAN PANK2

Target

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.

Partner Proteins

UBC; DHX36; QRICH2; LXN; YWHAQ; VDAC1; RASGRF2

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

PANK2 is supported by BioGPS gene expression data to be expressed in COLO205

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Sheep: 92%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

50kDa

Shipping Conditions

Wet Ice

Protein Length

460

NCBI Gene Symbol

PANK2

NCBI GB Accession Number

PANK2

Host or Source

Rabbit

Protein Name

Pantothenate kinase 2, mitochondrial

Peptide Sequence

FGLPGWAVASSFGNMMSKEKREAVSKEDLARATLITITNNIGSIARMCAL

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