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AMACR Antibody - C-terminal region : HRP (ARP60806_P050-HRP)

Selected Variant

ARP60806_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Alpha-methylacyl-CoA racemase

Gene Aliases

RM, RACE, CBAS4, P504S, AMACRD

Gene ID

23600

Swiss Prot

Q9UHK6

Accession Number

NP_055139

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human AMACR

Target

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R) - and (S) -stereoisomers. The conversion to the (S) -stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.

Partner Proteins

UBC; PEX5

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

IHC, WB

Purification

Affinity Purified

Sample Type

AMACR is strongly supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 100%; Guinea Pig: 77%; Horse: 85%; Human: 100%; Mouse: 77%; Pig: 85%; Rabbit: 82%; Rat: 85%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

42kDa

Shipping Conditions

Wet Ice

Protein Length

382

NCBI Gene Symbol

AMACR

NCBI GB Accession Number

AMACR

Host or Source

Rabbit

Protein Name

Alpha-methylacyl-CoA racemase

Nucleotide Accession Number

NM_014324

Peptide Sequence

IFDGTDACVTPVLTFEEVVHHDHNKERGSFITSEEQDVSPRPAPLLLNTP

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