TCHP Antibody - C-terminal region: FITC (ARP60515_P050-FITC)
Product Specifications
Gene Name
Trichoplein, keratin filament binding
Gene Aliases
TpMs
Gene ID
84260
Swiss Prot
Q9BT92
Accession Number
NP_115676
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human TCHP
Target
TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Partner Proteins
CCDC172; MIPOL1; DYDC1; KRT40; LZTS2; NME7; NDOR1; MKRN3; TRIM27; NAB2; KRT15; CDR2; UBC; LATS2; CUL4A; CCDC85B; TEX11; VIM; KRT18; KRT16; KRT14; KRT8; KRT6A; KRT5
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Yeast: 91%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
61kDa
Shipping Conditions
Wet Ice
Protein Length
498
NCBI Gene Symbol
TCHP
Protein Name
Trichoplein keratin filament-binding protein
Nucleotide Accession Number
NM_032300
Curated Selection
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