DDB2 Antibody - C-terminal region: FITC (ARP60163_P050-FITC)
Product Specifications
Gene Name
Damage-specific DNA binding protein 2, 48kDa
Gene Aliases
XPE, DDBB, UV-DDB2
Gene ID
1643
Swiss Prot
Q92466
Accession Number
NP_000098
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human DDB2
Target
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.
Partner Proteins
CUL4A; CUL4B; XPC; PARP1; UBC; SUMO1; SMEK1; COPG1; POP1; PSMB4; PSMB1; PSMA5; SEPT2; ARCN1; SUMO2; DDB1; USP24; USP53; RFWD2; COPS4; COPS6; COPS2; COPS3; XPA; TOP1; GRK5; EP300; COPS7A; COPS5; COPS8; RBX1; GPS1; E2F1; DDB2; CUL5; NEDD8; DCLRE1C; vpr; ERC
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 79%; Rabbit: 93%; Rat: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
48kDa
Shipping Conditions
Wet Ice
Protein Length
427
NCBI Gene Symbol
DDB2
Protein Name
DNA damage-binding protein 2
Nucleotide Accession Number
NM_000107
Curated Selection
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