DAXX Antibody - N-terminal region : Biotin (ARP60159_P050-Biotin)

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

FAM9B; SSX2IP; SUMO1; UBE2I; UBC; GOLGA2; CARD9; PBXIP1; CDCA7L; NECAB2; RASSF1; PML; MDM2; H3F3A; DNMT1; TP53; ATRX; CARM1; PRMT1; WHSC1L1; CUL3; SPOP; HIPK2; PDCD4; DNMT3A; USP7; UBB; RELB; DAXX; CREB1; CBS; ATM; HIST1H4F; HIST1H3C; TRAF3; HIST4H4; BTBD

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.