AP2A2 Antibody - C-terminal region: Biotin (ARP59974_P050-Biotin)

AP2A2 is a component of the adaptor protein complex 2 (AP-2) . AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif .

PIP5K1C; UBC; ATP1A1; SUMO2; EGFR; RPA3; RPA2; RPA1; BIN1; PPP6R3; PAN2; SMAD1; FN1; DAB2; VCP; APP; AP2A1; SHC1; GRK5; EPS15; AP2M1; CLTC; GRB2; ARRB2; Rnf111; TERF2; DNAJC6; SNAP91; EPN1; AP2A2; NUMB; AP1S1; DNM1; AP2B1; AMPH; HTT; ATR; ATM; RALBP1

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.