ADSL Antibody - middle region : Biotin (ARP59971_P050-Biotin)

Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.

CALCOCO2; REL; UBC; PDE12; BTF3L4; NPLOC4; EHD4; UBQLN2; NT5C2; WDR4; PAIP1; PLIN3; SAE1; OXSR1; API5; XPNPEP1; WARS; RAD23B; TWF1; DNAJB1; GTF2I; EIF1AX; DRG2; CTSC; NOV; TYMS; SUMO1; DDA1; USP15; USP4

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.