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RASSF1 Antibody - C-terminal region : FITC (ARP59681_P050-FITC)

Selected Variant

ARP59681_P050-FITC

Size: 100 µL

Product Specifications

Gene Name

Ras association (RalGDS/AF-6) domain family member 1

Gene Aliases

123F2, RDA32, NORE2A, RASSF1A, REH3P21

Gene ID

11186

Swiss Prot

Q9NS23

Accession Number

NP_733831

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human RASSF1

Target

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Partner Proteins

FBXW11; MDM2; DAXX; SUV39H2; KDM1A; SUV39H1; STK4; STK3; CDC20; SAV1; MAST2; HUWE1; LATS1; BTRC; UBC; ID1; GSK3B; C7orf25; C8orf33; KCNE3; CUL4A; DDB1; Rassf1; SKP2; AURKB; AURKA; SKP1; CUL1; NUDT10; MOAP1; CNKSR1; MAP1S; EXOSC8; RASSF5; TNFRSF10A; E4F1

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Sheep: 100%; Zebrafish: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

30kDa

Shipping Conditions

Wet Ice

Protein Length

270

NCBI Gene Symbol

RASSF1

NCBI GB Accession Number

RASSF1

Host or Source

Rabbit

Protein Name

Ras association domain-containing protein 1

Nucleotide Accession Number

NM_170713

Peptide Sequence

LAGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQIL

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