GCH1 Antibody - C-terminal region : FITC (ARP59618_P050-FITC)
Selected Variant
ARP59618_P050-FITC
Size: 100 µL
Product Specifications
Gene Name
GTP cyclohydrolase 1
Gene Aliases
GCH, DYT5, DYT14, DYT5a, GTPCH1, HPABH4B, GTP-CH-1
Gene ID
2643
Swiss Prot
P30793
Accession Number
NP_000152
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human GCH1
Target
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.
Partner Proteins
GCH1; CALML6; CAMKK1; CSNK1G1; CALML5; PACSIN3; RGS19; MAP2K4; MAPK12; MAP2K5; MAPK10; PRKAR2B; PRKAR2A; PPM1B; CSNK2B; CSNK2A1; GIT2; YWHAZ; CNRIP1; RAB26; AHSA1; SP3; RLF; HSPA8; GCHFR; ATP1B1; CDC37; SH3GL2; OSBPL9; RPH3A
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 85%; Zebrafish: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
28kDa
Shipping Conditions
Wet Ice
Protein Length
250
NCBI Gene Symbol
GCH1
NCBI GB Accession Number
GCH1
Host or Source
Rabbit
Protein Name
GTP cyclohydrolase 1
Nucleotide Accession Number
NM_000161
Peptide Sequence
LRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLT
Price
Sign In for Pricing
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC881867-500 1x 500 µL
CD8A (Cytotoxic-&Suppressor T-Cell Marker) (rC8/468), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
A01956-1-carrier-free 100 µg/Vial
Anti-Ferritin light chain/FTL Antibody Picoband®
Sign In for Pricing
View Details 
BNC472250-500 1x 500 µL
Squamous Cell Carcinoma Antigen 1 (CPTC-SERPINB3-2), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941553-100 1x 100 µL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740409-100 1x 100 µL
UPK3A (Uroplakin 3A) (Rabbit PAb), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC743134-100 1x 100 µL
GP2 (Glycoprotein 2) / ZAP75 (GP2/3134R), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details