PC Antibody - C-terminal region: Biotin (ARP59606_P050-Biotin)
Product Specifications
Gene Name
Pyruvate carboxylase
Gene Aliases
PCB
Gene ID
5091
Swiss Prot
P11498
Accession Number
NP_001035806
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human PC
Target
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.
Partner Proteins
HUWE1; SUMO2; UBC; SUMO1; MDM2; HECW2; ADRB2; IFIT1; PRKCDBP; PPT2; TUFM; RPS3A; NACA; MTHFD1; ILF3; ILF2; CDH2; UBE2N; NPM1; MDH2; GOT2; GOT1
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/mL
Homology
Cow: 86%; Dog: 86%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 86%; Rat: 86%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
127kDa
Shipping Conditions
Wet Ice
Protein Length
1178
NCBI Gene Symbol
PC
Protein Name
Pyruvate carboxylase, mitochondrial
Nucleotide Accession Number
NM_001040716
Curated Selection
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