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PC Antibody - C-terminal region : Biotin (ARP59606_P050-Biotin)

Selected Variant

ARP59606_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

Pyruvate carboxylase

Gene Aliases

PCB

Gene ID

5091

Swiss Prot

P11498

Accession Number

NP_001035806

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PC

Target

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

Partner Proteins

HUWE1; SUMO2; UBC; SUMO1; MDM2; HECW2; ADRB2; IFIT1; PRKCDBP; PPT2; TUFM; RPS3A; NACA; MTHFD1; ILF3; ILF2; CDH2; UBE2N; NPM1; MDH2; GOT2; GOT1

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 86%; Dog: 86%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 86%; Rat: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

127kDa

Shipping Conditions

Wet Ice

Protein Length

1178

NCBI Gene Symbol

PC

NCBI GB Accession Number

PC

Host or Source

Rabbit

Protein Name

Pyruvate carboxylase, mitochondrial

Nucleotide Accession Number

NM_001040716

Peptide Sequence

SLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPL

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