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PSENEN Antibody - C-terminal region : HRP (ARP59439_P050-HRP)

Selected Variant

ARP59439_P050-HRP

Size: 100 µL

Product Specifications

Gene Name

Presenilin enhancer 2 homolog (C. elegans)

Gene Aliases

PEN2, PEN-2, MDS033, ACNINV2, MSTP064

Gene ID

55851

Swiss Prot

Q9NZ42

Accession Number

NP_758844

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PSENEN

Target

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.

Partner Proteins

APH1A; ERLIN2; THBD; APH1B; PSEN2; PSEN1; TMED10; NCSTN

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

12kDa

Shipping Conditions

Wet Ice

Protein Length

101

NCBI Gene Symbol

PSENEN

NCBI GB Accession Number

PSENEN

Host or Source

Rabbit

Protein Name

Gamma-secretase subunit PEN-2

Nucleotide Accession Number

NM_172341

Peptide Sequence

SQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGT

Subunit

PEN-2

Price

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