PSENEN Antibody - C-terminal region : Biotin (ARP59439_P050-Biotin)
Product Specifications
Gene Name
Presenilin enhancer 2 homolog (C. elegans)
Gene Aliases
PEN2, PEN-2, MDS033, ACNINV2, MSTP064
Gene ID
55851
Swiss Prot
Q9NZ42
Accession Number
NP_758844
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human PSENEN
Target
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Partner Proteins
APH1A; ERLIN2; THBD; APH1B; PSEN2; PSEN1; TMED10; NCSTN
Clonality
Polyclonal
Conjugation
Biotin
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
12kDa
Shipping Conditions
Wet Ice
Protein Length
101
NCBI Gene Symbol
PSENEN
NCBI GB Accession Number
PSENEN
Host or Source
Rabbit
Protein Name
Gamma-secretase subunit PEN-2
Nucleotide Accession Number
NM_172341
Peptide Sequence
SQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGT
Subunit
PEN-2
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