PSMC6 Antibody - C-terminal region : HRP (ARP59359_P050-HRP)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.

SDCBP; CCDC146; CYB5R2; HUWE1; UBC; PSMD9; PSMC6; PSMC3; SUMO2; STAU1; PSMD14; MDM2; ABCF1; UBR4; ADRM1; TXNL1; AIMP1; AIMP2; RPS21; RPS15A; RPS12; RPS8; QARS; PSMD12; PSMD11; PSMD8; PSMD4; UCHL5; DYNC1LI1; PSMD3; PSMD2; PSMD1; PSMC5; PSMC2; PSMC1; PARK2

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.