PSMC6 Antibody - C-terminal region: FITC (ARP59359_P050-FITC)
Product Specifications
Gene Name
Proteasome (prosome, macropain) 26S subunit, ATPase, 6
Gene Aliases
P42, RPT5, SUG2
Gene ID
5706
Swiss Prot
P62333
Accession Number
NP_002797
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human PSMC6
Target
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
Partner Proteins
SDCBP; CCDC146; CYB5R2; HUWE1; UBC; PSMD9; PSMC6; PSMC3; SUMO2; STAU1; PSMD14; MDM2; ABCF1; UBR4; ADRM1; TXNL1; AIMP1; AIMP2; RPS21; RPS15A; RPS12; RPS8; QARS; PSMD12; PSMD11; PSMD8; PSMD4; UCHL5; DYNC1LI1; PSMD3; PSMD2; PSMD1; PSMC5; PSMC2; PSMC1; PARK2
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Sample Type
PSMC6 is supported by BioGPS gene expression data to be expressed in 721_B, MCF7
Concentration
0.5 mg/mL
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
44kDa
Shipping Conditions
Wet Ice
Protein Length
389
NCBI Gene Symbol
PSMC6
Protein Name
26S protease regulatory subunit 10B
Nucleotide Accession Number
NM_002806
Curated Selection
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