COPS6 Antibody - middle region : HRP (ARP59350_P050-HRP)

Product Specifications

Gene Name

COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)

Gene Aliases

CSN6, MOV34-34KD

Gene ID

10980

Swiss Prot

Q7L5N1

Accession Number

NP_006824

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human COPS6

Target

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.

Partner Proteins

NEDD8; CUL1; UBC; COPS5; GPS1; SUMO1; POP7; COPS7B; COPS7A; CUL4B; USP7; COPS4; FBXO6; FBXW4; IGHV3OR15-7; vpr; TP63; RFWD2; SFN; IRF5; COPS8; COPS2; COPS3; DDB2; DDB1; ERCC8; TOR1AIP2; LRR1; RBX1; VPRBP; LRRC14; CUL2; CUL3; CUL4A; CUL5; TCEB2; TCEB1; SKP

Clonality

Polyclonal

Conjugation

HRP: Horseradish Peroxidase

Type

Polyclonal Antibody

Applications

Purification

Affinity Purified

Sample Type

COPS6 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.