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USP6 Antibody - C-terminal region : Biotin (ARP59335_P050-Biotin)

Product Specifications

Gene Name

Ubiquitin specific peptidase 6 (Tre-2 oncogene)

Gene Aliases

HRP1, TRE2, TRE17, Tre-2, TRESMCR, USP6-short

Gene ID

9098

Swiss Prot

P35125-2

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human USP6

Target

USP6 is a deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. It catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. USP6 promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. It is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.

Partner Proteins

EXOSC8; CALM2; MDFI; APP; ATXN7L3; ANKRD44; RAB33B; MYL2; ARF6; RAC1; CDC42; UBC; USP32

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 91%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

119kDa

Shipping Conditions

Wet Ice

Product Datasheet

Anti-USP6 (ARP59335_P050-Biotin) antibody

Protein Length

1089

NCBI Gene Symbol

USP6

NCBI GB Accession Number

USP6

Host or Source

Rabbit

Protein Name

Ubiquitin carboxyl-terminal hydrolase 6

Peptide Sequence

NHSEEDSTDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCKWY

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