Arhgef4 Antibody - N-terminal region : FITC (ARP59254_P050-FITC)
Selected Variant
ARP59254_P050-FITC
Size: 100 µL
Product Specifications
Gene Name
Rho guanine nucleotide exchange factor (GEF) 4
Gene Aliases
As, Asef, 9330140K16Rik, C230030N03Rik
Gene ID
226970
Swiss Prot
Q7TNR9
Accession Number
NP_898840
Host
Rabbit
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Arhgef4
Target
Arhgef4 acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion By similarity. It is required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Arhgef4 is involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Cow: 79%; Dog: 93%; Guinea Pig: 92%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
57kDa
Shipping Conditions
Wet Ice
Protein Length
484
NCBI Gene Symbol
ARHGEF4
NCBI GB Accession Number
Arhgef4
Host or Source
Rabbit
Protein Name
Rho guanine nucleotide exchange factor 4
Nucleotide Accession Number
NM_183019
Peptide Sequence
ADDYEAPRAGAREADDSGPEAQSCKDQMRTNVINEILSTERDYIKHLRDI
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