TLR4 Antibody - middle region : Biotin (ARP59041_P050-Biotin)

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.

TNFSF9; SRC; SYK; SMAD3; SERTAD1; BTK; TICAM1; HGS; UBC; HSPA4; TICAM2; STK11IP; TIRAP; TRAF3; TRIM69; IRAK4; TBK1; STUB1; TRAF6; PRKCZ; MYD88; IRAK1; HSPA8; RNF216; CNPY4; SIGIRR; MAPK8IP3; NOX4; TOLLIP; LY96; BCL10; RIPK2; IRAK2; TLR5; DEFB4A; TLR1; HSP

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.