CASP4 Antibody - middle region: Biotin (ARP58991_P050-Biotin)

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

MYH9; ELF4; APP; TRAF6; PLA2G4A; NOD1; CASP14; CASP4; APAF1; SERPINB9; CASP10; IL18; CASP3; IL1B; DSP; PSEN1; IL37; CASP8; CASP1; XIAP; MYCBPAP; SLC25A22; SRPRB; CTNNBIP1; DNAAF5; MTHFD1L; UFL1; GCN1L1; SMC2; NUP93; SMC3; SMC1A; USP9X; VDAC3; PSMB1; MSH6

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.