CASP1 Antibody - middle region : Biotin (ARP58983_P050-Biotin)

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.

Ced-3; ced-4; VAC14; BCL2L1; UBC; XK; PLA2G4B; IL33; IL1B; PARP1; BIRC3; TRAF2; CEBPB; TIRAP; CARD17; CARD16; CARD8; PLA2G4A; CDK11B; NLRP1; ATN1; ATXN3; PYCARD; NLRC4; NOD1; CASP14; RIPK2; PAK1; PARK2; NEDD4; BID; IL18; PSEN2; NFE2L2; AR; BCAP31; MAPT; L

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.