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RUBCN Antibody - middle region : Biotin (ARP58950_P050-Biotin)

Selected Variant

ARP58950_P050-Biotin

Size: 100 µL

Product Specifications

Gene Name

RUN and cysteine rich domain containing beclin 1 interacting protein

Gene Aliases

SCAR15, RUBICON, KIAA0226

Gene ID

9711

Swiss Prot

Q92622-2

Accession Number

NP_001139114

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human KIAA0226

Target

The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Partner Proteins

BECN1; PIK3C3; EXOC8; EXOC2; EXOC1; PIK3R4; UVRAG; YWHAE; SMAD9

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 85%; Dog: 85%; Guinea Pig: 92%; Human: 100%; Mouse: 92%; Rabbit: 85%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

103kDa

Shipping Conditions

Wet Ice

Protein Length

927

NCBI Gene Symbol

RUBCN

NCBI GB Accession Number

RUBCN

Host or Source

Rabbit

Protein Name

Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

Nucleotide Accession Number

NM_001145642

Peptide Sequence

DQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP

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