PSEN1 Antibody - middle region : Biotin (ARP58941_P050-Biotin)

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

UBC; TRAF6; TGFBR1; ERLIN2; PSMB1; PSMA5; ETFA; TDP2; PSEN2; PSEN1; APH1B; PSENEN; APH1A; NCSTN; ITSN2; PDCD4; KANK2; EPB41L3; CDC37; TUBA1B; AP1M2; UMPS; PRDX2; ST13; SCN1A; RHEB; RAD23A; RAB3A; OXCT1; NOS3; NDUFS8; HMGB1; GCDH; GAPDH; FGF13; ENSA; DTNA

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.