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SHB Antibody - N-terminal region : FITC (ARP58763_P050-FITC)

Product Specifications

Gene Name

Src homology 2 domain containing adaptor protein B

Gene Aliases

BA3J10.2

Gene ID

6461

Swiss Prot

Q15464

Accession Number

NP_003019

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SHB

Target

SHB is the adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. SHB may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. SHB may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. SHB may also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Partner Proteins

SLC39A1; GRAP2; LAT; LCP2; EPS8; JAK3; IL2RG; KDR; SRC; ZAP70; PDGFRA; PLCG1; PIK3R1; VAV1; CRK; JAK1; IL2RB; GRB2; FGFR1; PDGFRB

Clonality

Polyclonal

Conjugation

FITC: Fluorescein Isothiocyanate

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Sample Type

SHB is supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

55kDa

References & Citations

Kriz, V., (2006) J. Biol. Chem. 281 (45), 34484-34491

Shipping Conditions

Wet Ice

Product Datasheet

Anti-SHB (ARP58763_P050-FITC) antibody

Protein Length

509

NCBI Gene Symbol

SHB

NCBI GB Accession Number

SHB

Host or Source

Rabbit

Protein Name

SH2 domain-containing adapter protein B

Nucleotide Accession Number

NM_003028

Peptide Sequence

ERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAY

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