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TMED10 Antibody - middle region : Biotin (ARP58728_P050-Biotin)

Product Specifications

Gene Name

Transmembrane emp24-like trafficking protein 10 (yeast)

Gene Aliases

P23, TMP21, p24d1, S31I125, Tmp-21-I, S31III125, P24 (DELTA)

Gene ID

10972

Swiss Prot

P49755

Accession Number

NP_006818

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TMED10

Target

TMED10 is involved in vesicular protein trafficking.This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8.

Partner Proteins

UBC; SUMO1; NEDD8; ASB8; RNF2; FBXO6; rev; TMED9; COPZ1; SEC23B; UBL4A; DHODH; ATF2; VCP; PTRF; S100A16; NIT2; PRDX6; SEC22B; EIF3C; VAMP2; COPG1; COPE; COPB2; COPB1; COPA; ARCN1; CDK2; EBNA-LP; RYK; TMED2; PSENEN; APH1A; NCSTN; ARF1; GORASP2

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

WB

Purification

Affinity Purified

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 82%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

Molecular Weight

24kDa

References & Citations

Dolcini, V., (2008) Biochem. Biophys. Res. Commun. 371 (1), 69-74

Shipping Conditions

Wet Ice

Protein Length

219

NCBI Gene Symbol

TMED10

NCBI GB Accession Number

TMED10

Host or Source

Rabbit

Protein Name

Transmembrane emp24 domain-containing protein 10

Nucleotide Accession Number

NM_006827

Peptide Sequence

KLKPLEVELRRLEDLSESIVNDFAYMKKREEEMRDTNESTNTRVLYFSIF

Frequently Asked Questions

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