TRPC6 Antibody - N-terminal region : FITC (ARP58718_P050-FITC)
Product Specifications
Gene Name
Transient receptor potential cation channel, subfamily C, member 6
Gene Aliases
TRP6, FSGS2
Gene ID
7225
Swiss Prot
Q9Y210
Accession Number
NP_004612
Host
Rabbit
Reactivity
Human, Mouse, Rat, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human TRPC6
Target
TRPC6 forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) .
Partner Proteins
RNF24; TRPC3; ORAI1; TRPM2; TRPC6; SRC; ITPR3; MX1; FYN; TRPC7; TRPC5; TRPC4; TRPC1; TRPC2; ITPR1
Clonality
Polyclonal
Conjugation
FITC: Fluorescein Isothiocyanate
Type
Polyclonal Antibody
Applications
WB
Purification
Affinity Purified
Concentration
0.5 mg/ml
Homology
Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Molecular Weight
106kDa
References & Citations
Liu, D., (2008) Arterioscler. Thromb. Vasc. Biol. 28 (4), 746-751
Shipping Conditions
Wet Ice
Protein Length
931
NCBI Gene Symbol
TRPC6
NCBI GB Accession Number
TRPC6
Host or Source
Rabbit
Protein Name
Short transient receptor potential channel 6
Nucleotide Accession Number
NM_004621
Peptide Sequence
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPC
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